Here you will find information about some of our experience in the
following categories of services:

Biostatistics
Protocol authoring
Epidemiology - study design
Epidemiology - analysis
Pharmaco-economics
Pharmaco-epidemiology
Clinical trial monitoring

 

Biostatistics

Non-comparative trial of an anorectic agent for the treatment of obesity

Metabolism

 

Non-comparative trial of a calcium channel blocking agent in mild to moderate arterial hypertension

Cardiology

 

Non-comparative trial for the evaluation of efficacy, tolerability and quality of life of a diuretic agent in arterial hypertension

Cardiology

Non-comparative trial of an anti-depressant agent

Psychiatry

Randomized comparative trial of a new calcium channel blocker in arterial hypertension

Cardiology

Cross-over trial of two vitaminic preparations in compressive lumbar radicular syndrome

Rheumatology

Non-comparative trial of a new anti-emetic agent in the prophylaxis of chemotherapy-induced nausea and vomiting

Oncology

Double-blind randomized trial of two anti-parkinsonic agents. Interim analysis

Neurology

Non-comparative trial for the evaluation of efficacy of a colony-stimulating factor in improving compliance with chemotherapy regimens

Oncology

Randomized comparative trial of a calcium channel blocker in mild to moderate arterial hypertension

Cardiology

Randomized comparative trial of a calcium channel blocker in mild to moderate arterial hypertension in patients with NIDDM

Cardiology

Non-comparative trial for the evaluation of the efficacy and tolerability of a new anti-emetic agent in the treatment of chemotherapy-induced nausea and vomiting

Oncology

Placebo-controlled comparative trial of an analgesic agent for the treatment of acute lumbar pain with a spastic component

Rheumatology

Non-comparative trial of a calcium channel blocking agent in patient with mild to moderate arterial hypertension and co-morbidities. Interim analysis

Cardiology

Randomized comparative trial of a new calcium channel blocker in mild to moderate arterial hypertension

Cardiology

Randomized trial of two corticosteroid preparations in the treatment of scalp psoriasis

Dermatology

Comparative trial of two colony stimulating factor in medullar transplant

Oncology

In vitro efficacy of a new quinolone antimicrobial

Microbiology

Dose titration trial of a calcium channel blocker in left ventricular hypertrophy secondary to arterial hypertension

Cardiology

Randomized, placebo-controlled trial of an analgesic/miorelaxant agent in acute lumbar pain with spastic component

Rheumatology

Comparative trial of two anti-parkinsonism agents. Second interim analysis

Neurology

Comparative trial of two posologies of an anti-hypertensive agent

Cardiology

Randomized, placebo-controlled trial of an analgesic/myorelaxant agent in acute lumbar pain with spastic component

Rheumatology

Dose titration trial of a calcium channel blocker in arterial hypertension in the elderly

Cardiology

Open trial for the evaluation of the efficacy and safety of an antidepressant agent

Psychiatry

Comparative trial of two topic corticosteroids in childhood atopic dermatitis

Dermatology

Non-comparative trial of a new calcium channel blocker in elderly patients with arterial hypertension and hyperglycemia or hyperlipidemia

Cardiology

Efficacy of an enti-emetic agent in Hodgkin's disease and chemotherapy

Oncology

Non-comparative trial of a calcium channel blocker in coronary heart disease with or without hypertension

Cardiology

Non-comparative trial of a calcium channel blocker in hypertensive patients with associated hyperglycemia or hyperlipidemia

Cardiology

Non-comparative trial of a calcium channel blocker in mild to moderate hypertension

Cardiology

Comparative trial of two anti-parkinson agents. Interim analysis

Neurology

Open trial of an ACE-inhibitor in mild to moderate hypertension

Cardiology

Randomized trial of a calcium channel blocker in mild to moderate hypertension

Cardiology

Placebo-controlled trial of a myo-relaxant agent in spasticity secondary to a cerebrovascular accident

Neurology

Open trial of an inhaled corticoid in bronchial asthma of the adult

Respiratory

Non-comparative trial of a third generation cephalosporyn in urinary tract infections

Urology

Non-comparative trial of a third generation cephalosporyn in ear infections

ENT

Non-comparative trial of a third generation cephalosporyn in acute medial otitis in children

ENT

Efficacy and safety of an ACE-inhibitor in the control of arterial hypertension evaluated by self-measurement

Cardiology

Clinical trial of a new NSAID in generalized osteoporosis

Rheumatology

Non-comparative trial of a systemic anti-allergic agent in children with atopic dermatitis and bronchial asthma

Allergy

Randomized trial of two anti-depressants in major depression and bipolar disorder. First interim analysis

Psychiatry

Non-comparative trial of an oral anti-diabetic agent in IDDM

Diabetes

Placebo-controlled trial of a colony-stimulating factor in the treatment of chronic leg ulcers

Dermatology

Open multicenter trial of an echographic contrast medium

Diagnosis

Phase II trial of a new chemotherapeutic agent in locally advanced or metastatic breast cancer

Oncology

Randomized trial of two anti-depressants in major depression and bipolar disorder

Psychiatry

Non comparative trial of a macrolide antimicrobial in lower respiratory tract infections in pediatric patients

Respiratory

Non comparative trial of a macrolide antimicrobial in lower respiratory tract infections in acute sinusitis

ENT

Comparative trial of two macrolide antimicrobials in lower tract respiratory infections

Respiratory

Placebo-controlled trial of an hypolipemiant agent in patients with dyslipidemia and arterial hypertension

Cardiology

Comparative trial of an alpha-adrenergic agent in patients with dyslipidemia and arterial hypertension

Cardiology

Placebo-controlled trial of a beta-lactamic antimicrobial in periodontitis

Dental

Efficacy and tolerability of prostate vaporization in benign prostate hypertrophy

Urology

Comparative trial of an angiotensin II receptor blocker versus a calcium channel blocker in arterial hypertension evaluated by ABPM dos canais de cálcio na hipertensão arterial avaliada por MAPA

Cardiology

Placebo-controlled trial of an oral antidiabetic agent in patients with NIDDM previously treated with sulphonylureas

Diabetes

Placebo-controlled trial of an oral antidiabetic agent in patients with NIDDM previously treated with diet alone

Diabetes

Phase II trial of a new chemotherapeutic agent in locally advanced or metastatic colorectal cancer

Oncology

Non-comparative single-blind trial of a NSAID in osteoarthritis

Rheumatology

Randomized trial of two NSAIDS in the relief of renal colic

Urology

Non-comparative trial of a new selective immunosupressor agent in active rheumatoid arthritis

Rheumatology

Non-comparative trial of a new anti-histamine agent in perennial allergic rhinitis

Allergy

Non-comparative trial of a new anti-histamine agent in allergic rhinitis associated with bronchial asthma

Allergy

Randomized trial of three formulations for the treatment of juvenile acne

Dermatology

Non-comparative trial of a new anti-histamine agent in perennial rhinitis associated with seasonal bronchial asthma

Allergy

Randomized, open-label trial of a new anti-histamine agent in chronic idiopathic urticaria

Allergy

Randomized, cross-over trial of a calcium channel blocker agent administered in the morning vs. in the evening, in patient with arterial hypertension

Cardiology

Randomized, cross-over trial of a calcium channel blocker agent administered in the morning vs. in the evening, in elderly patient with arterial hypertension

Cardiology

Pooled analysis of international randomized clinical trials on the efficacy of a monoclonal antibody in the treatment of patient with rheumatoid arthritis with loss of efficacy to MTX

Rheumatology

Non-comparative trial of the efficacy of an interferon on neuropsychologic symptoms in multiple sclerosis

Neurology

Randomized clinical trial of a statin vs. placebo on acute coronary syndromes

Cardiology

Non-comparative trial of the efficacy of an interferon on neuropsychologic symptoms in multiple sclerosis

Neurology

 





Protocol Authoring

Phase III randomized trial of two anti-parkinson agents

Neurology

Phase IV non-comparative trial of a third generation cephalosporyn in the treatment of acute amygdalo-pharyngitis

ENT

Phase IV non-comparative trial of a third generation cephalosporyn in the treatment of acute otitis media in the adult

ENT

Phase IV non-comparative trial of a third generation cephalosporyn in the treatment of urinary tract infections

Urology

Phase IV non-comparative trial of a third generation cephalosporyn in the treatment of acute otitis media in children

ENT

Pahase IV randomized trial of two antimicrobials in the treatment of acute tonsillitis in the adult

ENT

Phase IV randomized trial of a quinolone antimicrobial in the treatment of acute exacerbations of chronic bronchitis

Respiratory

Phase IV randomized trial of two antimicrobials in acute urinary tract infections

Urology

Phase IV randomized trial of two antimicrobials in acute otitis media in children

ENT

Phase III randomized placebo-controlled trial of a peripheral vasodilator agent for the treatment of vascular dementia

Neurology

Phase IV randomized trial of two topical agents in acute hemorrhoidary disease

Gastrenterology

Phase IV randomized trial of three topical agents in acute hemorrhoidary disease

Gastrenterology

Phase III randomized placebo-controlled trial of a venotropic agent for the treatment of chronic venous insufficiency

Angiology

Phase IV randomized trial comparing the efficacy of a combination of analgesic and myorelaxant with the individual components

Rheumatology

Phase III randomized placebo-controlled trial of a vasodilator agent for the treatment of chronic obstructive peripheral disease

Angiology

Phase III randomized placebo-controlled trial of a venotropic agent for the treatment of chronic venous insufficiency

Angiology

Phase III randomized placebo-controlled trial of a gallstone dissolution agent

Gastrenterology

Phase IV randomized trial of a combination of an hypolipemiant agent plus a vitamin with the hypolipemiant agent alone, in lipid reduction therapy

Cardiology

Phase III randomized placebo-controlled trial of a peripheral vasodilator in vascular dementia

Neurology

 





Epidemiology - study design

Epidemiology of chronic venous insufficiency in the community

Angiology

Epidemiological features of chronic venous insufficiency in the community

Angiology

Risk factors of chronic venous insufficiency in the community

Angiology

Epidemiology of respiratory diseases in the community

Respiratory

Epidemiology of allergic rhinitis in the community

Allergology

Epidemiology of isolated systolic hypertension in the community

Cardiology

Epidemiology of chronic heart failure in the community

Cardiology

Epidemiology of chronic heart failure in Madeira island

Cardiology

Incidence and prevalence of ostomy, demographics and clinical profile of ostomates

Nursing

Epidemiology of chronic hepatitis C

Hepatology

Natural history of chronic hepatitis C undergoing initial combination therapy

Hepatology

Quality of life of ostomates and their caregivers

Nursing

 



Epidemiology - analysis

Risk factors for hepatitis B

 

Gastrenterology

Epidemiology of chronic venous insufficiency in the community

Angiology

Epidemiological features of chronic venous insufficiency in the community

Angiology

Risk factors of chronic venous insufficiency in the community

Angiology

Epidemiological survey on undiagnosed arterial hypertension

Cardiology

Validation study of self-measurement of arterial blood pressure

Cardiology

Diabetes screening

Diabetes

Epidemiology of osteoporosis in the community

Rheumatology

Epidemiology of benign prostate hyperplasy

Urology

Validation study of a structured interview for the diagnosis of mental disorders

Psychiatry

Prevalence and risk factor for respiratory diseases in the community

Respiratory

Epidemiology of allergic rhinitis in the community

Allergy

Determinations of reference values for respiratory parameters from a community sample of normal subjects

Respiratory

Analysis of environmental factors in a large company

Occupational

Risk factors for respiratory diseases in the community

Respiratory

Response to bronchodilatation testes in a community sample

Respiratory

Validation study of a structured interview for the evaluation of depression

Psychiatry

Screening for hypertension and hypercholesterolemia in the community

Cardiology

Screening diabetes mellitus in the population

Diabetes

Epidemiology of isolated systolic hypertension in the Portuguese population

Cardiology

Evaluation of a smoking-cessation program in the community

Cardiology

Epidemiology of migraine in primary care

Neurology

Incidence and prevalence of ostomy in Portugal

Nursing

Epidemiology of chronic hepatitis C in Portugal

Hepatology

Prevalence of coronary heart disease in primary care

Cardiology

Quality of life of ostomates and their caregivers

Nursing

Evaluation of a direct to consumer campaign in improving blood pressure control

Cardiology

 




Pharmaco-economics

Pharmaco-economic study of a DMARD in rheumatoid arthritis

Rheumatology

Pharmaco-economic study of chronic C hepatitis treatment

Gastrenterology

Pharmaco-economic evaluation of a cholinergic agent versus a comparator in urinary incontinence

Urology

Pharmaco-economic evaluation of the non-specific and COX2 NSAID agents in osteoarthritis

Rheumatology

 




Pharmaco-epidemiology

Pharmaco-epidemiology of NSAID utilization in osteoarthritis

Rheumatology

Longitudinal pharmaco-epidemiological study of NSAID utilization in osteoarthritis

Rheumatology

Treatment practices in hospitalized community-acquired pneumonia. A Delphi study

Respiratory

Treatment of heart failure in patients with acute myocardial infarction

Cardiology

Determinants of use of antibiotic therapy in acute tonsillitis in primary care

Infectious

 



Clinical trial monitoring

Pathology

Number of trials

Number of centers

Rheumatoid arthritis

1

12

Bronchial asthma

3

24

Colorectal cancer

1

12

Breast cancer

1

10

Cholelythiasis

1

14

Diabetes mellitus

4

26

Alzheimer's disease

1

4

Coronary heart disease

2

33

Parkinson's disease

1

9

Chronic pain

1

7

COPD

3

15

Arterial hypertension

1

15

Chronic venous insufficiency

2

22

Microbiology

1

6

Pyelonefritis

1

6

Periodontitis

1

5

Diabetic retinopathy

2

4

Prostate cancer

1

7

Major Depression

1

6

Multiple sclerosis

4

42

 Stroke prevention

1

8

Total

34

288